Bioorganic and Medicinal Chemistry Letters p. 4245 - 4249 (2009)
Update date:2022-08-03
Topics:
Petrocchi, Alessia
Jones, Philip
Rowley, Michael
Fiore, Fabrizio
Summa, Vincenzo
A novel class of tetrahydro-pyrazinopyrimidine-2-carboxamides have been identified as HIV-1 integrase inhibitors. Optimization of the initial lead culminated in the discovery of a series of compounds with high potency on the enzyme and an antiviral cell-b
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