Journal of labelled compounds and radiopharmaceuticals p. 229 - 235 (2006)
Update date:2022-08-03
Topics:
Oba, Makoto
Ohkuma, Kosuke
Hitokawa, Hiroshi
Shirai, Ayumi
Nishiyama, Kozaburo
Novel 3,4-didehydropyroglutamate derivatives, the key intermediates in this synthesis, were obtained from a protected pyroglutamate by the well-known selenenylation-oxidative deselenenylation method and were catalytically deuterated using a slow-addition technique. The obtained deuterated pyroglutamates were converted to [3,4-2H2]glutamic acid, [3,4,5-2H3]proline, and [3,4,5,5,5-2H 5]leucine via an appropriate functional group interconversions followed by the standard deprotection procedure. Copyright
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