A practical synthesis of 2′-aminoacylamino-2′-deoxyadenosines

Article abstract of DOI:10.1016/j.tet.2007.04.038

A practical and efficient synthesis of 2′-aminoacylamino-2′-deoxyadenosine derivatives is reported. EDCI/HOBt-mediated coupling of a 3′,5′-diprotected 2′-amino-2′-deoxyadenosine derivative to various N-Cbz-l-amino acid derivatives followed by global depro