Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKCδ

DOI: 10.1021/jm0702579

Source and publish data:

Journal of Medicinal Chemistry p. 3465 - 3481 (2007)

Update date:2022-08-03

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Authors:

Choi, Yongseok

Pu, Yongmei

Peach, Megan L.

Kang, Ji-Hye

Lewin, Nancy E.

Sigano, Dina M.

Garfield, Susan H.

Blumberg, Peter M.

Marquez, Victor E.

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Article abstract of DOI:10.1021/jm0702579

Diacylglycerol (DAG) lactones have provided a powerful platform for structural exploration of the interactions between ligands and the C1 domains of protein kinase C (PKC). In this study, we report that DAG-dioxolanones, novel derivatives of DAG-lactones,

Full text of DOI:10.1021/jm0702579

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