A New Route to 3,5-Disubstituted Isoxazolidines via the Iodocyclization of Homoallylic Hydroxylamines

DOI: 10.1021/jo00013a032

Source and publish data:

Journal of Organic Chemistry p. 4246 - 4252 (1991)

Update date:2022-08-02

Topics:

Authors:

Mancini, Fabrizio

Piazza, Maria Giulia

Trombini, Claudio

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Article abstract of DOI:10.1021/jo00013a032

N,N-Dialkyl-O-trialkylsilyl homoallylic hydroxylamines reacted with iodine, N-iodosuccinimide, or iodine chloride to give 3,5-disubstituted isoxazolidines in good yield.The relative configuration that was generated at C3 and C5 was controlled by the natur

Full text of DOI:10.1021/jo00013a032

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