SYNTHESE TOTALE DE STEROIDES A CYCLE C AROMATIQUE

Article abstract of DOI:10.1016/S0040-4020(01)91335-3

The ring-C aromatic analogue 4 of 4-androstene 3,17-dione and its 11 hydroxylated(methoxylated) derivatives 20a(b) were prepared by a practical synthetic route.The key steps of the sequence are achieved in superacid: the cyclisation of diarylethane 5a to phenanthrenone 17, and the hydroxylation by hydrogenperoxide of ketone 4 to phenol 20a.