LIPASE-CATALYZED ASYMMETRIC SYNTHESIS OF CHIRAL 1,3-PROPANEDIOLS AND ITS APPLICATION TO THE PREPARATION OF OPTICALLY PURE BUILDING BLOCK FOR RENIN INHIBITORS

Article abstract of DOI:10.1016/S0040-4039(01)93338-6

Asymmetric synthesis of chiral 2-substituted-1,3-propanediols was realized the lipase-catalyzed transesterification in vinyl acetate and it was applied to the synthesis of an optically active sulfone derivate.