Transition-State Properties and Rate-Limiting Processes in the Acetylation of Acetylcholinesterase by Natural and Unnatural Substrates

Article abstract of DOI:10.1021/ja00526a052

The acetylation of acetylcholinesterase at pH 7.5 and 25.00 deg C proceeds at the same rate to within a few percent for acetylcholine, CD3CO2CH2CH2N(CH3)3⁺, CH3CO2CD2CH2N(CH3)3⁺, and CH3CO2CH2CD2N(CH3)3⁺ and possibly sligh