Peroxynitrite Decomposition to Nitrosating Species
Chem. Res. Toxicol., Vol. 15, No. 4, 2002 511
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both. Any of these possibilities supports the view that
peroxynitrite and its derived radicals contribute to tissue
pathology in inflammatory conditions.
Ack n ow led gm en t. We thank Dr. Dulcine´ia S. P.
Abdalla for providing access to the nitric oxide analyzer.
This work was partially supported by grants to O.A. from
Fundac¸a˜o de Amparo a` Pesquisa do Estado de Sa˜o Paulo
(FAPESP), Conselho Nacional de Desenvolvimento Ci-
ent´ıfico e Tecnolo´gico (CNPq), and Financiadora de
Estudos e Projetos (FINEP).
(20) Hodges, G. R., and Ingold, K. U. (1999) Cage-escape of geminate
radical pairs can produce peroxynitrate from peroxynitrite under
a wide variety of experimental conditions. J . Am. Chem. Soc. 121,
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B., Bohle, D. S., and Mayer, B. J . (1997) Metabolic fate of
peroxynitrite in aqueous solutionsReaction with nitric oxide and
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