Green Chemistry p. 6630 - 6636 (2016)
Update date:2022-08-29
Topics:
Rassadin, Valentin A.
Zimin, Dmitry P.
Raskil'dina, Gulnara Z.
Ivanov, Alexander Yu.
Boyarskiy, Vadim P.
Zlotskii, Semen S.
Kukushkin, Vadim Yu.
A novel solvent- and halide-free atom-economical synthesis of practically useful pyridine-2-yl substituted ureas utilizes easily accessible or commercially available pyridine N-oxides (PyO) and dialkylcyanamides. The observed C-H functionalization of PyO is suitable for the good-to-high yielding synthesis of a wide range of pyridine-2-yl substituted ureas featuring electron donating and electron withdrawing, sensitive, or even fugitive functional groups at any position of the pyridine ring (63-92%; 19 examples). In the cases of 3-substituted PyO, the C-H functionalization occurs regioselectively providing a route for facile generation of ureas bearing a 5-substituted pyridine-2-yl moiety.
View MoreHangzhou Dingyan Chem Co., Ltd
website:http://www.dingyanchem.com
Contact:86-571-87157530-8007
Address:RM.1118,NO.1 Building, Baiyun Tower,Jianggan Area, Hangzhou city, China,310004
Contact:0086 533 2282832
Address:Zibo,Shandong
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.
Contact:0086-0576-88551200,88886292 ,88880039
Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China
Antaeus Bio-technology Co., LTD
Contact:021-31252569
Address:shanghai pudong
QINGDAO HONG JIN CHEMICAL CO.,LTD.
website:http://www.hongjinchem.com
Contact:+86-532-83657313
Address:2ND Building, 8 Shangqing Road, Qingdao, Shandong Province, China.
Doi:10.1007/BF00961527
(1990)Doi:10.1016/S0040-4039(01)89722-7
(1967)Doi:10.1002/chem.201701704
(2017)Doi:10.1021/j100065a043
(1994)Doi:10.1021/ja301528w
(2012)Doi:10.1021/acs.jmedchem.8b00246
(2018)