Isomerization of uroporphyrinogen I octamethyl ester through spiro- pyrrolenine intermediate

Article abstract of DOI:10.1016/S0040-4039(99)00400-1

Treatment of uroporphyrinogen I octamethyl ester with 2- mercaptobenzothiazolylmethyl pyrrole derivative in the presence of silver (I) trifrate under anaerobic condition in dichloromethane for 20 h, followed by aerial oxidation of the products, gave a statistical mixture of uroporphyrin I~IV octamethyl esters. It was proposed that this transformation proceeds through a spiro-pyrrolenine as a key intermediate.