Synthesis of an oxyamide linked nucleotide dimer and incorporation into antisense oligonucleotide sequences

DOI: 10.1039/c39940000915

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 915 - 916 (1994)

Update date:2022-08-05

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Authors:

Burgess Burgess

Gibbs Gibbs

Metzker Metzker

Raghavachari

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Article abstract of DOI:10.1039/c39940000915

Two derivatives of thymidine, a 5'-protected 3'-hydroxylamine and 5'-carboxy-3'-protected compound, were prepared and coupled to form an oxyamide-linked dinucleotide analogue; this dimer was incorporated into an oligodeoxynucleotide then shown to anneal t

Full text of DOI:10.1039/c39940000915

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