Asymmetric Synthesis using Chiral Bases: Enantioselective α-Alkylation of Carboxylic Acids

DOI: 10.1039/c39870000656

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Journal of the Chemical Society. Chemical communications p. 656 - 658 (1987)

Update date:2022-08-17

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Authors:

Ando, Akira

Shioiri, Takayuki

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Article abstract of DOI:10.1039/c39870000656

Enantioselective alkylation of carboxylic acids (1) and (2) at the α-position can be performed using the chiral lithium isopropylamides (3) or (4), which function as both a strong base and a chiral auxiliary.

Full text of DOI:10.1039/c39870000656

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