A new route to α-hetero β-enamino esters using a mild and convenient solvent-free process assisted by focused microwave irradiation

Article abstract of DOI:10.1016/S0040-4039(98)01894-2

New α-hetero β-enamino esters 5 (X = NH, O, S) are obtained in good to excellent yields by transamination reactions from ethyl 3-dimethylamino acrylate 2(a-c) and various volatile amines 3(a-e) using solvent-free conditions assisted by focused microwave irradiation. Most of the α-hetero β-enamino ester derivatives 3 present a (E)s-cis/trans conformation.