Journal of Pharmaceutical Sciences p. 461 - 463 (1988)
Update date:2022-08-29
Topics:
Tu
Konno
Soejarto
Waller
Bingel
Molyneux
Edgar
Cordell
Fong
The MeOH extract of Senecio vulgaris L., administered po to rats on Days 1-10 postcoitum, significantly decreased the number of normal fetuses per pregnant rat found at autopsy on Day 16. Additional experiments showed a similar activity for its hepatotoxic constituents senecionine and senecionine N-oxide, suggesting that the latter two compounds were probably responsible for the effect seen with the extract. No antifertility effects were seen in MeOH extract-treated hamsters.
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