A Synthetic Approach towards Octalactin A, Based on the Stereoselective Reduction of α,β-Unsaturated Ketones

Article abstract of DOI:10.1016/0040-4039(95)00498-2

An efficient enantioselective synthesis of the C3-C9 fragment of Octalactin A and studies aimed at the conversion of Octalactin B into Octalactin A are described, which are based on the borane-mediated reduction of α,β-unsaturated ketones catalysed by B-m