Stereoselective radical-mediated cyclization of norephedrine derived o-bromobenzamides: Enantioselective synthesis of 4-substituted 1,2,3,4-tetrahydroisoquinolines

DOI: 10.1016/S0957-4166(00)82347-2

Source and publish data:

Tetrahedron Asymmetry p. 273 - 280 (1993)

Update date:2022-08-11

Topics:

Authors:

Belvisi Belvisi

Gennari Gennari

Poli Poli

Scolastico

Salom Salom

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Article abstract of DOI:10.1016/S0957-4166(00)82347-2

Radical-mediated cyclization of norephedrine derived o-bromobenzamide 5 was found to be fairly stereoselective (85:15) favouring diastereoisomer trans-6. Tricyclic δ-lactams 6 were transformed in high yield into enantiomerically enriched (R)-1,2,3,4-tetra

Full text of DOI:10.1016/S0957-4166(00)82347-2

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