Biological and Pharmaceutical Bulletin p. 1617 - 1619 (1995)
Update date:2022-08-29
Topics:
Kimura
Yasukawa
Takido
Akihisa
Tamura
The oxygenated stigmastane-type sterols stigmastane-3β,6α-diol, stigmastane-3β,6α-diol, 7α-hydroxysitosterol and its diacetyl derivative, 7β-hydroxysitosterol and its diacetyl derivative, 7-oxositosterol, 4β- hydroxysitosterol, and stigmast-4-ene-3β,6β-diol were evaluated with respect to their anti-inflammatory activity against 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. All of the sterols, with the exception of 7α-hydroxysitosterol and its diacetyl derivative, were found to possess marked inhibitory activity. The 50% inhibitory dose of these compounds for TPA-inflammation (1 μg) was 0.5-1.0 mg/ear.
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