Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

DOI: 10.1016/S0223-5234(97)81682-0

Source and publish data:

European Journal of Medicinal Chemistry p. 453 - 456 (1997)

Update date:2022-08-16

Topics:

Authors:

Masereel

Ouedraogo

Dogne Dogne

Antoine Antoine

De Tullio

Pirotte Pirotte

Pochet Pochet

Delarge Delarge

Lebrun Lebrun

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0223-5234(97)81682-0

Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.

Full text of DOI:10.1016/S0223-5234(97)81682-0

Products guided by the article

Product name:N-[1-(methylthio)-2-nitroethenyl]cyclohexanamine

Cas No:148342-52-3

R&D Labs maybe for 148342-52-3

Weifang Dongxing Chitosan Factory

website:http://dxchitosan.lookchem.com/

Contact:13475651157

Address:Weifang city ,shandong province
shanghai tuomiao chemicial co.,ltd.

website:https://www.tuomiaochem.com/

Contact:021 - 59853336

Address:shanghai
Hisyntech Corporation Limited

Contact:0086-22-23410962

Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
shandong zhongke taidou chemical co.,ltd

Contact:86-531-88682301

Address:Jinan shandong Province CHina
HAORUI ENTERPRISES LLC

Contact:(1) 206-3550089

Address:5115 NE 8TH PL, Renton, WA 98059 USA

Relevant to this article

A new efficient photosensitizer for nanocrystalline solar cells: Synthesis and characterization of m-bis(4,7-dicarboxy-l,10phenanthroline)dithiocyanato ruthenium(n)

Doi:10.1039/b002391o
(2000)
7b-Methyl-7bH-cyclopentindene, an Unsubstituted Tricyclic Aromatic <10>Annulene

Doi:10.1039/c39810000657
(1981)
Palladium-Catalyzed Synthesis ofΔ²-Isoxazoline from Toluene Derivatives Enabled by the Triple Role of Silver Nitrate

Doi:10.1021/acs.orglett.5b03059
(2015)
Immobilized heterobimetallic Ru/Co nanoparticle-catalyzed Pauson-Khand-type reactions in the presence of pyridylmethyl formate

Doi:10.1039/b304325h
(2003)
Enantioselective Synthesis of Functionalized Diazaspirocycles from 4-Benzylideneisoxazol-5(4H)-one Derivatives and Isocyanoacetate Esters

Doi:10.1002/adsc.202000611
(2020)
Synthesis of methyl Β-alkylcarboxylates by Pd/diphosphine-catalyzed methoxycarbonylation of methylenealkanes RCH₂CH₂C(R)=CH₂

Doi:10.1016/j.apcata.2019.05.030
(2019)

Article Doi