European Journal of Medicinal Chemistry p. 453 - 456 (1997)
Update date:2022-08-16
Topics:
Masereel
Ouedraogo
Dogne
Antoine
De Tullio
Pirotte
Pochet
Delarge
Lebrun
Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.
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