PHENYLPROPANOIDS AND OTHER DERIVATIVES FROM THAPSIA VILLOSA

Article abstract of DOI:10.1016/S0031-9422(00)83124-6

Key Word Index - Thapsia villosa; Umbelliferae; roots; phenylpropanoids; hemanticine; guaianolides; thapsivillosin K. - Five phenylpropanoids related to hemanticine have been obtained from Thapsia villosa roots.We propose for these substances the trivial names isohelmanticine, neohelmanticine, isoneohelmanticine, epoxyhelmanticine and epoxyhelmanticine angelate.All these substances are based on (1S,2R)1-(3-methoxy-4,5-methylenedioxyphenyl)-1,2-propanediol, which is esterified variously by acetic, angelic, epoxyangelic and/or (2R,3S)2,3-dihydroxy-2-methylbutyric acids.We also report three C₆-guaianolides and their hydrolysis products.The name thapsivillosin K is proposed for a new guaianolide.