2-(Trimethylsilyl)ethyl as a Phosphate Protecting Group in Oligonucleotide Synthesis

DOI: 10.1016/S0040-4039(00)75810-2

Source and publish data:

Tetrahedron Letters p. 757 - 760 (1994)

Update date:2022-08-18

Topics:

Authors:

Wada, Takeshi

Sekine, Mitsuo

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Article abstract of DOI:10.1016/S0040-4039(00)75810-2

The 2-(trimethylsilyl)ethyl (TSE) group was found to be effective as a protecting group for the internucleotidic phosphate in oligonucleotide synthesis.Phosphoramidite building blocks having the TSE group were prepared in good yields.In the case of deoxyg

Full text of DOI:10.1016/S0040-4039(00)75810-2

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Product name:Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-(trimethylsilyl)ethyl bis(1-methylethyl)phosphoramidite]

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