Chemical and Pharmaceutical Bulletin p. 1703 - 1705 (1994)
Update date:2022-08-16
Topics:
Ohwada
Umeda
Ontsuka
Aoki
Shimma
A new antifungal substance, azoxybacilin (an unusual amino acid with an azoxy moiety) and its derivatives have been synthesized from Boc-L-Asp-O(t)Bu utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative, Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.
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