Synthesis and structure-activity relationships of a novel antifungal agent, azoxybacilin

DOI: 10.1248/cpb.42.1703

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1703 - 1705 (1994)

Update date:2022-08-16

Topics:

Authors:

Ohwada Ohwada

Umeda Umeda

Ontsuka Ontsuka

Aoki Aoki

Shimma Shimma

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Article abstract of DOI:10.1248/cpb.42.1703

A new antifungal substance, azoxybacilin (an unusual amino acid with an azoxy moiety) and its derivatives have been synthesized from Boc-L-Asp-O(t)Bu utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative, Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.

Full text of DOI:10.1248/cpb.42.1703

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