Synlett p. 909 - 910 (1997)
Update date:2022-08-17
Topics:
Mittra, Asmita
Yamashita, Masayuki
Kawasaki, Ikuo
Murai, Hiromichi
Yoshioka, Tomomichi
Ohta, Shunsaku
An easy and convenient synthesis of 3-alkanoyl-5-hydroxymethyltetronic acids, the salts of which have inhibitory activity against HIV-1 protease, is described and a new direct route to 1,3-dicarbonylester from cyclic β-ketoester is developed.
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