Enantioselective Synthesis of α-Functionally Substituted Cyclic Ketones via Chiral Organotin Enamines

Article abstract of DOI:10.1021/jo00220a036

Chiral organotin enamines 1a-f are easily prepared from cyclic ketones, chiral amino alcohols 5a-c (derived from amino acids), and an organotin precursor.Nucleophilic addition of these compounds to electrophilic alkenes followed by hydrolysis leads to the