Bioorganic and Medicinal Chemistry Letters p. 1013 - 1018 (1999)
Update date:2022-08-16
Topics:
Lee, Koo
Hwang, Sang Yeul
Park, Cheol Won
A series of novel arylsulfonylpropargylglycinamide derivatives was investigated as thrombin inhibitors in which the SAR was focused on substituents at the acetylchic terminus. Several compounds in this series were identified as potent thrombin inhibitors (Ki up to 5 nM) that are highly selective over trypsin and other serine proteases as well.
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