
Journal of the Chemical Society. Perkin transactions I p. 753 - 754 (1996)
Update date:2022-08-30
Topics:
Okada, Yoshio
Wang, Jidong
Yamamoto, Takeshi
Mu, Yu
Nπ-2-Adamantyloxymethylhistidine, His(Nπ-2-Adom), is prepared and successfully applied to the synthesis of thyrotropin-releasing hormone (TRH) in combination with tert-butyloxycarbonyl (Boc) as the Nα-protecting group. This new protecting group suppressed racemization during peptide synthesis and exhibited high solubility in organic solvents.
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