Phytochemistry p. 1585 - 1588 (1982)
Update date:2022-08-24
Topics:
Pfitzner, Artur
Stoeckigt, Joachim
The characterization and partial purification of geissoschizine dehydrogenase from Catharanthus roseus cell suspension cultures are described.The 35-fold purified enzyme removes the 21α-hydrogen of geissoschizine in a NADP+-dependent reaction.NAD+, FAD or FMN cannot act as cofactors for the dehydrogenation.Structurally related indole alkaloids are not dehydrogenated.In comparison to enzymes of the ajmalicine pathway, geissoschizine dehydrogenase shows an extremely low specific activity. - Key Word Index: Catharanthus roseus; Apocynaceae; geissoschizine dehydrogenase; stereospecificity; biosynthesis; heteroyohimbine alkaloids; cell suspension culture.
View More
Shanghai Pinewood Fine Chemical Co., Ltd.
website:http://www.pinewoodchem.com
Contact:0086-21-62417129，62414096
Address:Suite B, 27F, No.2, Lane 600, Tianshan Road, Shanghai
Jiaxing Taixin Pharmaceutical Chemical Co., Ltd
Contact:0573-82613601
Address:Chemical Park, Jiaxing, Zhejiang, China
Jiangsu Zenji Pharmaceuticals LTD
Contact:+86-025-83172562; +1-224-888-1133(USA)
Address:No.5 Xinmofan Road
Contact:+86-15850770348
Address:51 OF XIANGFANGCUN ROAD, Nanjing 210002, China
Shanghai Forever Synthesis Co.,Ltd.
Contact:021-61124658
Address:Zhoukang Road,Pudong New District,Shanghai,China
Doi:10.1016/j.jorganchem.2011.02.016
(2011)Doi:10.1021/jo0511400
(2005)Doi:10.1016/j.tetlet.2006.10.038
(2006)Doi:10.1016/0022-328X(90)85219-O
(1990)Doi:10.1002/1521-3773(20011001)40:19<3596::AID-ANIE3596>3.0.CO;2-C
(2001)Doi:10.1055/s-0040-1708004
(2020)
