Propargyloxycarbonyl and propargyl groups for novel protection of amino, hydroxy, and carboxy functions

Article abstract of DOI:10.1016/S0040-4039(98)02555-6

The propargyloxycarbonyl group readily introduced to both amino and hydroxy groups by using propargyl chloroformate is stable to neat TFA but is readily cleaved at ambient temperature by treatment with Co₂(CO)₈ and TFA in CH₂Cl₂ via formation of an alkyne-Co complex. The propargyl ester similarly serves as a good protecting group for carboxy functions.