A convenient synthesis of 2'- or 4'-hydroxycocaine

Article abstract of DOI:10.1080/00397919708005923

A short, convenient and efficient synthesis of 2'- or 4'-hydroxycocaine is described. The key step involved selective hydrolysis/transesterification of the acetoxy group of 2'- or 4'-acetoxycocaine in methanol saturated with dry HCl gas.

Full text of DOI:10.1080/00397919708005923

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Synthetic Communications: An
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Organic Chemistry
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A Convenient Synthesis of 2′-
OR 4′-Hydroxycocaine
a
a
Satendra Singh , Garo P. Basmadjian , Kwasi Avor
a
a
b
,
Buddi Pouw & Thomas W. seale
a
Department of Medicinal Chemistry and
Pharmaceutics , College of Pharmacy
b
Department of Pediatrics, Psychiatry and
Behavioral Science , College of Medicine, University
of Oklahoma Health Sciences Center , OK, Oklahoma
City, 73190, U.S.A.
Published online: 22 Aug 2006.
To cite this article: Satendra Singh , Garo P. Basmadjian , Kwasi Avor , Buddi Pouw
&
Thomas W. seale (1997) A Convenient Synthesis of 2′- OR 4′-Hydroxycocaine,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 27:22, 4003-4012
To link to this article: http://dx.doi.org/10.1080/00397919708005923
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