Synthesis of N-quaternary ammonium [3H] and [(99m)Tc]Polyazamacrocycles, potential radiotracers for cartilage imaging

Article abstract of DOI:10.1002/(SICI)1099-1344(200005)43:6<585::AID-JLCR343>3.0.CO;2-H

The [³H] and [(99m)Tc] synthesis of three new compounds, N-[3-(pyridinio)propyl] cyclam (NPPC), N-[3-(triethylammonium)propyl] cyclam (NTPC) and N-[3-(triethylammonium)propyl]-15ane-N5 (NTP 15-5), potential tracers for cartilage, is reported. NPPC and NTPC were labelled with tritium on the ethyl group of cyclam with a specific radioactivity of 89 MBq/mmol. The [(99m)Tc]-labelling of the three quaternary ammonium chelates was realized with a high specific activity in the range 20-25 MBq/μmol.