CHROMIC ANHYDRIDE-3,5-DIMETHYLPYRAZOLE COMPLEX: AN EFFICIENT REAGENT FOR OXIDATION OF STEROIDAL ESTROGENS TO 6-OXO-DERIVATIVES

Article abstract of DOI:10.1016/0039-128X(83)90145-9

An efficient procedure for the oxidation of steroidal estrogens to the corresponding 6-oxo-derivatives is described.The oxidative process involves the use of 3,5-dimethylpyrazole-chromium trioxide complex at low temperature (-20 deg).Under these conditions, only the 6-oxo-derivative and the unreacted starting material were obtained and the latter could be subjected to oxidation once again to obtain additional amount of 6-oxo-derivative.