Bioorganic and Medicinal Chemistry Letters p. 433 - 436 (1997)
Update date:2022-08-17
Topics:
Chiou, Tzyy-Wen
Chang, Cheng-Chi
Lai, Chung-Torr
Tai, Dar-Fu
An enzymatic method for the direct resolution of propranolol is described. Candida cylindracea lipase enantioselectively catalyzed N-acetylation of S-propranolol with isopropenyl acetate in isopropyl ether. The ee values of the two enantiomers of N-acetylpropranolol were determined by an HPLC equipped with a chiral column. The effects of organic solvent nature and substrate concentration on enantioselectivity were also studied.
View More
Nanjing Chemical Material Corp.(NCMC)
website:http://www.njchemm.com
Contact:0086-25-83172879
Address:B12 Technology and Innovation Building, Nanjing Tech University, No.5 New Model Road
Jiangsu Chiatai Qingjiang Pharmaceutical Co.,Ltd
Contact:+86-517-86283327
Address:9 North Hantai Road, Huaian, China
Dongying J&M Chemical Co., Ltd,
Contact:546-8551108
Address:Room 1219, Zisheng Mansion, Zibo Road, Dongying, Shandong, China
Jining tiansheng chemical co.,ltd.
Contact:+86-537-5158722
Address:ROOM 1011, BLOCK B, CUIDU INTERNATIOAL BUSINESS CENTER, JINING CITY, CHINA
Guangzhou Probig Fine Chemical Co., Ltd.
Contact:020-86297874
Address:No.2, 1/F, No.20, Hetai Road,Hebian Village, Baiyun District,Guangzhou,China
Doi:10.1248/cpb.40.786
(1992)Doi:10.1021/jo01069a041
(1961)Doi:10.1016/j.bioorg.2020.103819
(2020)Doi:10.1016/0022-2852(90)90062-U
(1990)Doi:10.1246/cl.2001.512
(2001)Doi:10.1016/j.poly.2021.115054
(2021)
