Bioorganic and Medicinal Chemistry Letters p. 433 - 436 (1997)
Update date:2022-08-17
Topics:
Chiou, Tzyy-Wen
Chang, Cheng-Chi
Lai, Chung-Torr
Tai, Dar-Fu
An enzymatic method for the direct resolution of propranolol is described. Candida cylindracea lipase enantioselectively catalyzed N-acetylation of S-propranolol with isopropenyl acetate in isopropyl ether. The ee values of the two enantiomers of N-acetylpropranolol were determined by an HPLC equipped with a chiral column. The effects of organic solvent nature and substrate concentration on enantioselectivity were also studied.
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