An improved synthesis of β-Nicotyrine from the dehydrogenation of nicotine: Comparison of conventional and microwave-assisted reactions

Article abstract of DOI:10.1081/SCC-120023988

β-Nicotyrine, a minor tobacco alkaloid, can be rapidly prepared in good yield from the dehydrogenation of S-(-)-nicotine over MnO₂ with microwave irradiation. This method is superior to dehydrogenation reactions that utilize S-(-)-nicotine and MnO₂ in a variety of solvents under reflux.