Anti-complement activity of tiliroside from the flower buds of Magnolia fargesii

Article abstract of DOI:10.1248/bpb.21.1077

As part of the search for anticomplementary active components from natural products, the anticomplementary properties of methanolic extracts from the flower buds of Magnolia fargesii have been investigated. Bioassay- guided chromatographic Separation of the active constituents led to the isolation of compound 1, whose structure was identified by spectroscopic methods to be kaempferol 3-O-β-D-(6_-O-coumaroyl)glucopyranoside (tiliroside). Tiliroside showed very potent anti-complement activity (IC₅₀=5.4x 10^-5 M) on the classical pathway of the complement system, even higher than rosmarinic acid, which is a well-known inhibitor against the complement system. On the other hand, the hydrolysates of tiliroside, kaempferol, astragalin and p-coumaric acid showed very weak activity on this system.

Full text of DOI:10.1248/bpb.21.1077

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