Synthesis, lipophilicity and biological evaluation of indole-containing derivatives of 1,3,4-thiadiazole and 1,2,4-triazole

Article abstract of DOI:10.1016/S0014-827X(98)00024-X

3-[(2-Methyl-1H-3-indolyl)methyl]-4-aryl-4,5-dihydro-1H-1,2,4-triazole- 5-thiones 6a-c and their respective N-{5-[(2-methyl-1H-3-indolyl) methyl] - 1,3,4-thiadiazol-2-yl }-N-arylamines 7a,b have been prepared. The antidepressant profile of 6a,c and 7a was