Journal of the Chemical Society, Dalton Transactions p. 1083 - 1086 (1984)
Update date:2022-08-11
Topics:
Hay, Robert W.
Pujari, Mahesh P.
The palladium(II)-promoted hydrolysis of methyl glycylglycinate and isopropyl glycylglycinate has been studied at four temperatures (25, 30, 35, and 40 deg C) at I=0.1 mol dm-3 in the pH range 4-5.Under these conditions, and at a 1:1 metal to ligand ratio, the peptide esters act as tridentate ligands, donation occuring via the terminal amino-group, the deprotonated amide nitrogen, and the carbonyl group of the ester.Rate constants are reported for hydrolysis of the ester function by water and hydroxide ion, and activation parameters calculated.Base hydrolysis of the co-ordinated peptide esters is ca. 1E5 times faster than the unproto nated peptide esters.Mechanisms for the reactions are considered.
Contact:+49-4101-3053-0
Address:Waldhofstrasse 14 ,25474 Ellerbek Germany
Nanjing distinctions Medical Technology Co., Ltd.(expird)
Contact:+86-15996203785 13914714059
Address:nanjing,jiangsu , China
Jintan City Mego Chemical Co., Ltd
Contact:+86-0519-82814387
Address:23# Dengguan Town, Jintan, Jiangsu Province, China
Shanghai better-in Medical Technology Co.,LTD.
Contact:+86-21-38921049
Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
website:http://www.arromax.com
Contact:+86-0512-62959601 skype:aimmezhang
Address:Suite 401, Bldg A3, 218 Xinghu St.Suzhou Industrial Park 215123, P.R. China
Doi:10.1016/j.bmc.2016.01.055
(2016)Doi:10.1002/jccs.200700018
(2007)Doi:10.1021/jo962408d
(1997)Doi:10.1016/S0040-4039(03)01593-4
(2003)Doi:10.1021/jo9701288
(1997)Doi:10.1016/j.bmcl.2013.05.015
(2013)
