Bioorganic and Medicinal Chemistry Letters p. 1541 - 1542 (1996)
Update date:2022-08-11
Topics:
Bihovsky, Ron
Pendrak, Israil
The reported calpain inhibitor cystamidin A (1a, pyrrole-3-propanamide) and a regioisomer, pyrrole-2-propanamide (1b) have been synthesized from the corresponding pyrrolecarboxaldehydes. The previously assigned structure of cystamidin A is confirmed. However, neither synthetic cystamidin A nor regioisomer 1b inhibits recombinant human calpain I.
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