Lactic Acid

Base Information

• Chemical Name: Lactic Acid
• CAS No.: 26100-51-6
• Deprecated CAS: 152-36-3,598-82-3,1334714-39-4,1334714-39-4,598-82-3,849585-22-4
• Molecular Formula: C₃H₆O₃
• Molecular Weight: 90.0788
• Hs Code.: 3907700000
• European Community (EC) Number: 200-018-0,295-890-2,209-954-4,825-250-5
• ICSC Number: 0501
• NSC Number: 367919
• UN Number: 3265
• UNII: 3B8D35Y7S4
• DSSTox Substance ID: DTXSID7023192
• Nikkaji Number: J1.358G
• Wikipedia: Lactic acid
• Wikidata: Q161249
• NCI Thesaurus Code: C80130,C71947,C76926
• RXCUI: 1314409,28393
• Metabolomics Workbench ID: 122706
• ChEMBL ID: CHEMBL1200559
• Mol file: 26100-51-6.mol

Synonyms:2 Hydroxypropanoic Acid;2 Hydroxypropionic Acid;2-Hydroxypropanoic Acid;2-Hydroxypropionic Acid;Ammonium Lactate;D Lactic Acid;D-Lactic Acid;L Lactic Acid;L-Lactic Acid;Lactate;Lactate, Ammonium;Lactic Acid;Propanoic Acid, 2-Hydroxy-, (2R)-;Propanoic Acid, 2-Hydroxy-, (2S)-;Sarcolactic Acid

Chemical Property of Lactic Acid

Chemical Property:

• Melting Point: 16.8oC
• Boiling Point: 227.6°Cat760mmHg
• Flash Point: 109.9°C
• PSA: 57.53000
• Density: 1.276g/cm³
• LogP: -0.54820
• Storage Temp.: 2-8°C
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 90.031694049
• Heavy Atom Count: 6
• Complexity: 59.1
• Transport DOT Label: Corrosive

Purity/Quality:

99% ^*data from raw suppliers

Polylactic acid Mw ~60,000 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 22-24/25-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Organic Acids
• Canonical SMILES: CC(C(=O)O)O
• Recent ClinicalTrials: Exploring the Effect of Lactate Administration After Ischemic Stroke on Brain Metabolism
• Recent EU Clinical Trials: Assessment of the effects on barrier impairment, clinical features and bacterial colonization of topical formulations in patients with atopic eczema; a phase IIa, single-center, randomized, observer-blind study
• Recent NIPH Clinical Trials: SYNbiotics Effect Research after sleeve Gastrectomy In Severely obese patients on intestinal flora: a double blind, randoMized controlled trial
• Inhalation Risk: No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes. The substance is irritating to the skin and respiratory tract. Corrosive on ingestion.
• General Description: Polylactic acid (PLA), also known as propanoic acid, 2-hydroxy-, homopolymer, is a biodegradable polymer with significant potential in medical, agricultural, and packaging applications due to its controllable stereochemistry and microstructure. The polymerization of lactide using zinc and magnesium β-diiminate complexes, such as [(BDI-1)ZnOiPr]2, enables precise stereocontrol, yielding isotactic, heterotactic, or syndiotactic PLA with narrow polydispersities and living polymerization characteristics. The substituents on the β-diiminate ligand play a critical role in determining both the stereoselectivity and polymerization rate, making these catalysts highly effective for producing tailored PLA materials.

Technology Process of Lactic Acid

There total 479 articles about Lactic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

acetylacetone (123-54-6,81235-32-7) → LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + 2-acetoxypropionic acid (535-17-1) + Ethylene glycol di-tert-butyl diether (26547-47-7) + 3-acetoxy-3-methylbutanoic acid (44983-17-7) + 2,5-hexanedione (110-13-4) + D,L-lactide (95-96-5,26680-10-4,26969-66-4,615-95-2)

Guidance literature:

With dihydrogen peroxide; In tert-butyl alcohol; for 36h; Reflux;

DOI:10.1007/s11172-013-0316-6

Reference yield:

rhodamine B (81-88-9) → phenylacetic acid (103-82-2) + glycolic Acid (79-14-1) + LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + propylene glycol (57-55-6,63625-56-9) + cyclohexen-1-ol (4065-81-0) + 1.3-butanediol (18826-95-4,107-88-0) + 4-Methyl-1-pentanol (626-89-1) + terephthalic acid (100-21-0) + Phthalic acid dibutyl ester (84-74-2) + 2-Phenylbutyric acid (90-27-7) + cyclohexanol (108-93-0)

Guidance literature:

for 0.5h; pH=5; UV-irradiation; Darkness;

DOI:10.1016/j.apcata.2013.01.035

Reference yield:

butyric acid (107-92-6) → methanol (67-56-1) + formic acid (64-18-6) + glycolic Acid (79-14-1) + LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + 4-hydroxybutanoic acid (591-81-1) + acetaldehyde (75-07-0,9002-91-9) + acetic acid (64-19-7,77671-22-8) + acetone (67-64-1) + 3-Hydroxybutyric acid (300-85-6,625-71-8,26063-00-3,29435-48-1) + 2-Hydroxybutanoic acid (600-15-7,565-70-8)

Guidance literature:

With potassium tetrachloroplatinate; iron(II) chloride tetrahydrate; sulfuric acid; oxygen; In water; at 150 ℃; for 6h; under 15001.5 Torr; Catalytic behavior;

DOI:10.1002/chem.201901803

upstream raw materials:

propan-1-ol

D-Fructose

D-Mannose

Glyceraldehyde

Downstream raw materials:

formic acid-(4-phenylazo-anilide)

2-hydroxy-1-(2-hydroxy-3-isopropyl-6-methyl-phenyl)-propan-1-one

lactic acid-(2-benzyloxy-ethyl ester)

acetic acid

Refernces

Polymerization of lactide with zinc and magnesium β-diiminate complexes: Stereocontrol and mechanism

10.1021/ja003851f

This research study on the polymerization of lactide using zinc and magnesium β-diiminate complexes, with a focus on stereocontrol and mechanism. The purpose of the study was to develop single-site metal catalysts capable of controlling the stereochemistry of poly(lactic acid) (PLA), a biodegradable polymer with potential applications in medical, agricultural, and packaging fields. The researchers synthesized a series of zinc(II) and magnesium(II) alkoxides based on a β-diiminate ligand framework and found that [(BDI-1)ZnOiPr]2 exhibited the highest activity and stereoselectivity among the zinc complexes studied. This complex was able to polymerize rac- and meso-lactide to PLA with high control over the stereochemistry, resulting in isotactic, heterotactic, and syndiotactic PLA microstructures. The polymerizations were found to be living, as evidenced by narrow polydispersities and linear relationships between number average molecular weight and conversion plots. The study concluded that the substituents on the β-diiminate ligand significantly influenced the stereoselectivity and polymerization rate.