8006-71-1

Basic information

• Product Name: piperazine hydrochloride
• Synonyms: Einecs 231-422-5;Piperazine, hydrochloride (1:1)
• CAS NO: 8006-71-1
• Molecular Formula: C4H11ClN2
• Molecular Weight: 0
• Mol File: 8006-71-1.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: piperazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: piperazine hydrochloride(8006-71-1)
• EPA Substance Registry System: piperazine hydrochloride(8006-71-1)

Safety Data

• Hazardous Substances Data: 8006-71-1(Hazardous Substances Data)

Upstream product

• 7647-01-0 hydrogenchloride 
• 67-56-1 methanol 
• 110-85-0 piperazine 
• 75-36-5 acetyl chloride 
• 290-37-9 1,4-pyrazine 
• 142-64-3 piperazine dihydrochloride 
• 111-41-1 2-(2-Aminoethylamino)ethanol 
• 4261-68-1 1-chloro-2-diisopropylaminoethane hydrochloride 
• 7542-23-6 piperazine hydrochloride 
• 31166-44-6 phenylmethyl 1-piperazinecarboxylate 
• 5700-04-9 1,3-diazacycloheptane-2-thione 
• 6328-56-9 1,4-bis-(2-chloro-propionyl)-piperazine 
• 5712-71-0 1-(2-hydroxyethyl)piperazine dihydrochloride 
• 75-44-5 phosgene 

Downstream Products

• 100861-65-2 1-(3-o-tolyloxy-propyl)-piperazine 
• 55455-92-0 1-(3-phenylpropyl)piperazine 
• 13754-38-6 N-Benzoylpiperazine 
• 72141-41-4 (4-nitro-phenyl)-piperazin-1-yl-methanone 
• 304510-78-9 C₁₈H₁₆F₂N₂O₂ 
• 139516-64-6 1-(2-fluorobenzoyl)-piperazine 
• 88372-33-2 2-phenyl-1-(piperazin-1-yl)ethanone 
• 102391-98-0 1-(4-fluorobenzoyl)piperazine 
• 194943-60-7 2-(2-fluorophenyl)-1-(piperazin-1-yl)ethanone 
• 1356998-49-6 C₂₀H₂₀F₂N₂O₂ 
• 1094292-19-9 2-(4-methylphenyl)-1-(piperazin-1-yl)ethanone 
• 926254-27-5 2-(3-methoxyphenyl)-1-(piperazin-1-yl)ethanone 
• 138768-65-7 C₁₈H₁₈N₆ 
• 57260-68-1 2-piperazin-1-yl-1H-benzoimidazole 

Relevant articles and documents

Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions?

Hydrogenation of over a dozen aromatic compounds, including both heteroarenes and arenes, over palladium on carbon (Pd/C, 1–100 molpercent) with H2-balloon pressure at room temperature is reported. Analyses using pyridine as a model substrate revealed that acetic acid was the best solvent, as using only 1 molpercent Pd/C provided piperidine quantitatively. Substrate scope analysis and density functional theory calculations indicated that reaction rates are highly dependent on frontier molecular orbital characteristics and the steric bulkiness of substituents. Moreover, the established method was used for the concise synthesis of the anti-Alzheimer drug donepezil (Aricept?).

A N, 6 diphenyl pyrimidine -4 - amine Bcr - Abl inhibitor and its preparation method and application (by machine translation)

The invention discloses a N, 6 diphenyl pyrimidine - 4 - amine Bcr - Abl inhibitor and its preparation method and application, the structural formula of the inhibitor for the wherein R is a single substituent or double-substituent, substituent is alkyl or halogen; R1 As a single substituent or double-substituent, substituent is alkyl or halogen. The series of inhibitors in vitro ABL1 kinase restraining effects, and can inhibit the proliferation of tumor cells, can be used for anti-tumor pharmaceutical preparation, in particular CML (chronic granulocytic leukemia) drug. The invention provides N, 6 diphenyl pyrimidine - 4 - amine Bcr - Abl inhibitor preparation method, raw materials are apt, mild reaction conditions, the reaction process is simple in operation, reagent used and cheap. (by machine translation)

A Arylheterocycle chirality bcr - abl inhibitor and its preparation method and application

The invention discloses aromatic heterocyclic biphenyl Bcr-Abl inhibitors as well as a preparation method and application thereof. A structural formula of the inhibitors is shown in the specification, wherein in the structural formula, Ar is aromatic heterocycle; R is a mono-substituent or a di-substituent, and the substituent is alkyl or halogen. The series of inhibitors have a certain inhibiting effect on ABL1 kinase in vitro, can inhibit tumor cell proliferation and can be used for preparing antitumor drugs, especially CML (chronic myelocytic leukemia) drugs. The preparation method of the aromatic heterocyclic biphenyl Bcr-Abl inhibitors, which is provided by the invention, has the advantages of easiness in obtainment of raw materials, mild reaction conditions, simplicity in operation of reaction processes and cheap used reagents.