Organocatalytic Asymmetric Cascade Michael-Michael Reaction of 2-Hydroxy-3-phenyl-propenal (1a) with trans-β-Nitrostyrene (2a)

June 13, 2024

• Title:       

  Organocatalytic Asymmetric Cascade  Michael-Michael Reaction of 2-Hydroxy-3-phenyl-propenal  (1a) with trans-β-Nitrostyrene (2a)

• Image Source:

  Catalytic asymmetric oxa-Michael-Michael cascade for facile construction of chiral chromans via an aminal intermediate

• Mark:

  Table 1

• Associated context:

  In our exploratory study, we decided to choose 2-hydroxy cinnamaldehyde 1a and trans-β-nitrostyrene 2a as substrates for the proposed cascade oxa-Michael-Michael reaction in the presence of a chiral amine in CH₂Cl₂ (CAS 75-09-2) at it since the aldehyde and nitro groups are highly versatile functionalities in organic transformations (Table 1).