Synthesizing R-keto esters and amides via oxidative cleavage of CdP double bonds followed by trapping with alcohols and amines, respectively

June 14, 2024

• Title:       

  Synthesizing R-keto esters and amides via oxidative cleavage of CdP double bonds followed by trapping with alcohols and amines, respectively

• Image Source:

  Synthesis of α-keto esters and amides via oxidative cleavage of cyanoketophosphoranes by dimethyldioxirane

• Mark:

  Scheme 1

• Associated context:

  Wasserman and co-workers devised an efficient method for synthesizing R-keto esters and amides via oxidative cleavage of CdP double bonds followed by trapping with alcohols and amines, respectively (Scheme 1).3 This method has been employed in the synthesis of a variety of enzyme inhibitors such as poststatin, eurystatin A, YM-47141, and YM-47142.