Hydrothiolation of 4-chlorostyrene 1 with diphenyl disulfide 67 in different reaction conditions

July 02, 2024

• Title:       

  Hydrothiolation of 4-chlorostyrene (CAS 1073-67-2) 1 with diphenyl disulfide (CAS 882-33-7) 67 in different reaction conditions

• Image Source:

  Iron-catalysed Markovnikov hydrothiolation of styrenes

• Mark:

  Scheme 4

• Associated context:

  However, a possible redox reaction between the thiol and the iron center (2RSH+2Fe³⁺→RSSR+2H⁺+2Fe²⁺) should not be discarded. A second experiment was conducted by adding pmethoxythiophenol 9 (1 equiv.) along with 4-chloros-tyrene land diphenyl disulfide 67 (0.5 equiv.; Scheme 5) and it was found that thiol exchange indeed occurs, even in the absence of iron(Il) or alkene( (Supporting Information, Scheme S2).