Retrosynthetic Analysis

July 17, 2024

• Title:       

  Retrosynthetic Analysis

• Image Source:

  Synthesis of the C1-C20 and C15-C27 Segments of Aplyronine A

• Mark:

  Scheme 1

• Associated context:

  As outlined in Scheme 1, the synthetic approach is based on the disconnection of macrocyclic lactone 2 and side-chain 3. Macrocyclic core 2 is accessed from building blocks 4, 5, 6, 7, and 8. Segments 4, 7, and 8 are derived by vinyl sulfone strategies creating stereodefined polypropionate fragments.