The sulfonamide 9j was prepared from 3-iodobenzyl bromide by displacement of bromide with sodium sulfit

July 26, 2024

• Title:       

  The sulfonamide 9j was prepared from 3-iodobenzyl bromide by displacement of bromide with sodium sulfit

• Image Source:

  Synthesis and structure-activity relationships of long-acting β2 adrenergic receptor agonists incorporating arylsulfonamide groups

• Mark:

  Scheme 2

• Associated context:

  The intermediate iodo- or bromo-arenesulfonamides (9 and  10, respectively) were prepared by reaction of the respective sulfonyl chlorides with the appropriate amine or ammonia. The sulfonamide 9j was prepared from 3-iodobenzyl bromide by displacement of bromide with sodium sulfite, followed by conversion to the sulfonyl chloride and then reaction with aqueous ammonia (Scheme 2).