We tried different approaches to synthesize (S)-1

July 26, 2024

• Title:       

  We tried different approaches to synthesize (S)-1

• Image Source:

  Chiral monofluorobenzyl carbanions: Synthesis of enantiopure β-fluorinated β-phenylethylamines

• Mark:

  Scheme 3

• Associated context:

  We tried different approaches to synthesize (S)-1 (Scheme 3).[19] Reactions of (S)-4 with fluorinating electrophilic reagents (NFSI and Selectfluor, among others)[6] and those of the bromoderivative (S)-5 with different fluoride sources, when using ionic liquids,[20] were unsuccessful.