Synthesis of Furanopyrimidine Derivatives

August 14, 2024

• Title:       

  Synthesis of Furanopyrimidine Derivatives

• Image Source:

  Structure-based design of novel Chk1 inhibitors Insights into hydrogen bonding and protein-ligand affinity

• Mark:

  Scheme 1

• Associated context:

  The other analogs (12-15) of compound  1 shown in Table 2 were synthesized in-house following published procedures 47 (Scheme 1). Thus, condensation of the commercially available aminofuran (16), with in situ generated acetic formic anhydride gave the N-  formyl derivative (17).