Synthesis of Pyrrolopyrimidine Derivatives

August 14, 2024

• Title:       

  Synthesis of Pyrrolopyrimidine Derivatives

• Image Source:

  Structure-based design of novel Chk1 inhibitors Insights into hydrogen bonding and protein-ligand affinity

• Mark:

  Scheme 2

• Associated context:

  The pyrrolopyrimidines were prepared from the commercially available analogue 21 (Scheme 2). This was debenzylated with aluminum chloride in refluxing toluene to give the derivative 22 in 54% yield, based on the recovered starting material. The anilino derivatives were prepared by microwave irradiation of precursor 22  with 6 equiv of the corresponding amine in ethanol at  100 °C. Purification of the crude material using column chromatography gave the pure pyrrolopyrimidines in 10-20% yield.