Two-directional synthesis of bifurans

August 14, 2024

• Title:       

  Two-directional synthesis of bifurans

• Image Source:

  Palladium-catalyzed asymmetric synthesis of 2-alkynyl oxacycles

• Mark:

  Table 3

• Associated context:

  The high kinetic selectivity exhibited in the cyclization ought to permit the stereodefined synthesis of such frameworks, and towards this end, we prepared a selection of substrates to investigate a two-directional formation of bicyclic oxacycles.[8]  Our prediction for these substrates (12a–d, Table 3) was that the bifuran product 13 would be kinetically favored over the fused-ring pyranopyran 14.