4519-40-8

Basic information

• Product Name: 2,3-Difluoroaniline
• Synonyms: 2,3-DIFLUOROANILINE;2,3-Difluorobenzenamine;TIMTEC-BB SBB006565;2,3-Difluoroaniline,98%;2,3-Difluoroaniline 98%;2,3-difluorophenylamine;Benzenamine, 2,3-difluoro-;2,3-Difluoroaniline, 98% 1GR
• CAS NO: 4519-40-8
• Molecular Formula: C₆H₅F₂N
• Molecular Weight: 129.11
• EINECS: 224-847-2
• Product Categories: Other fluorin-contained compounds;Fluorobenzene Series;Fluorobenzene;Amines and Anilines;Anilines, Aromatic Amines and Nitro Compounds;Aniline;Miscellaneous;Amines;C2 to C6;Nitrogen Compounds
• Mol File: 4519-40-8.mol

Chemical Properties

• Boiling Point: 68-69 °C
• Flash Point: 160 °F
• Appearance: Clear light orange/Liquid
• Density: 1.274 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.08mmHg at 25°C
• Refractive Index: n20/D 1.514(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.19±0.10(Predicted)
• BRN: 2716500
• CAS DataBase Reference: 2,3-Difluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Difluoroaniline(4519-40-8)
• EPA Substance Registry System: 2,3-Difluoroaniline(4519-40-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-27-28-36/37/39-36
• RIDADR: 2941
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4519-40-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Difluoroaniline is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique structure allows it to be a key component in the synthesis of ethyl 2-arylamino-4-trifluoromethylpyrimidine-5-carboxylate, which may have potential applications in the treatment of certain diseases.
Used in Chemical Synthesis:
Due to its distinct chemical properties, 2,3-difluoroaniline can be employed as a building block in the synthesis of a wide range of organic compounds. Its reactivity and stability make it a valuable asset in the development of new materials and chemicals for various applications.

InChI:InChI=1/C6H5F2N/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2

Synthetic route

2,3-dibromo-5,6-difluoroaniline → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; triethylamine In methanol at 50℃; for 3h;	98%

1,2-dibromo-4,5-difluoro-3-nitrobenzene (1481-57-8) → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; triethylamine In methanol at 50℃; for 2.5h; Temperature;	93%

1-(2,3-difluorophenyl)pyrrolidine-2,5-dione → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
With hydrogenchloride In water for 1h; Reflux;	89.1%

1-(6-amino-2,3-difluorophenyl)pyrrolidine-2,5-dione → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
Stage #1: 1-(6-amino-2,3-difluorophenyl)pyrrolidine-2,5-dione With sulfuric acid; acetic acid; sodium nitrite at 5℃; for 0.5h; Stage #2: With ethanol; zinc for 1.5h; Reflux;	83.6%
Multi-step reaction with 2 steps 1.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 5 °C 1.2: 1 h / 50 °C 2.1: hydrogenchloride / water / 1 h / Reflux View Scheme

1,2,3-trichlorobenzene (87-61-6) → 2,3-difluoroanilline (4519-40-8) + 2,6-difluoroaniline (5509-65-9)

Conditions	Yield
With ammonium hydroxide; cesium fluoride; copper(I) oxide 1.) N,N'-dimethylethyleneurea, 250 deg C (bomb), 12 h, 2.) 170 deg C (bomb), 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
With ammonium hydroxide; cesium fluoride; copper(I) oxide 1.) N,N'-dimethylethyleneurea, 250 deg C (bomb), 12 h, 2.) 160 deg C (bomb), 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;

difluorotrichloronitrobenzene + isopropyl alcohol (67-63-0) → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
With hydrogen; sodium formate; palladium on charcoal

difluorodichlorobenzene (36556-39-5) + 1-chloro-3,5-difluorobenzene (1435-43-4) + 3,4,5-trichloro-2,6-difluoronitrobenzene (136272-32-7) + 1,2,4-trichloro-3,5-difluoronitrobenzene (136272-33-8) → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
With sulfuric acid; nitric acid; sodium acetate; chlorine; aluminium trichloride; palladium on charcoal In methanol; dichloromethane

ortho-difluorobenzene (367-11-3) → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: iron; bromine / 4.83 h / 20 - 50 °C 2: sulfuric acid; nitric acid / water / 1.5 h / 20 - 35 °C 3: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 2.5 h / 50 °C View Scheme
Multi-step reaction with 4 steps 1: iron; bromine / 4.83 h / 20 - 50 °C 2: sulfuric acid; nitric acid / water / 1.5 h / 20 - 35 °C 3: iron; calcium chloride; ethanol; water / 3.2 h / 55 °C 4: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 3 h / 50 °C View Scheme

1,2-difluoro-4,5-dibromobenzene (64695-78-9) → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / water / 1.5 h / 20 - 35 °C 2: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 2.5 h / 50 °C View Scheme
Multi-step reaction with 3 steps 1: sulfuric acid; nitric acid / water / 1.5 h / 20 - 35 °C 2: iron; calcium chloride; ethanol; water / 3.2 h / 55 °C 3: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 3 h / 50 °C View Scheme

1,2-dichloro-4,5-difluoro-3-nitrobenzene → 2,3-difluoroanilline (4519-40-8) + 2,3-dichloro-5,6-difluoroaniline

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; triethylamine In methanol at 45℃; for 4.2h; Temperature;

ortho-difluorobenzene (367-11-3) → 2,3-difluoroanilline (4519-40-8) + 2,3-dichloro-5,6-difluoroaniline

Conditions	Yield
Multi-step reaction with 3 steps 1: iron(III) chloride; chlorine / 9 h / 48 - 54 °C 2: sulfuric acid; nitric acid / water / 7 h / 20 - 26 °C 3: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 4.2 h / 45 °C View Scheme

1,2-dichloro-4,5-difluorobenzene → 2,3-difluoroanilline (4519-40-8) + 2,3-dichloro-5,6-difluoroaniline

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / water / 7 h / 20 - 26 °C 2: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 4.2 h / 45 °C View Scheme

2,3,4-trifluoronitrobenzene (771-69-7) → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C 2.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere 3.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 5 °C 3.2: 1.5 h / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: ammonium hydroxide / ethanol / 8 h / 20 °C 2.1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 7 h / Dean-Stark; Reflux 3.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere 4.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 5 °C 4.2: 1.5 h / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C 2.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere 3.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 5 °C 3.2: 1 h / 50 °C 4.1: hydrogenchloride / water / 1 h / Reflux View Scheme
Multi-step reaction with 5 steps 1.1: ammonium hydroxide / ethanol / 8 h / 20 °C 2.1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 7 h / Dean-Stark; Reflux 3.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere 4.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 5 °C 4.2: 1 h / 50 °C 5.1: hydrogenchloride / water / 1 h / Reflux View Scheme

2-amino-3,4-difluoronitro-benzene (211693-73-1) → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 7 h / Dean-Stark; Reflux 2.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere 3.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 5 °C 3.2: 1.5 h / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 7 h / Dean-Stark; Reflux 2.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere 3.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 5 °C 3.2: 1 h / 50 °C 4.1: hydrogenchloride / water / 1 h / Reflux View Scheme

1-(2,3-difluoro-6-nitrophenyl)pyrrolidine-2,5-dione → 2,3-difluoroanilline (4519-40-8)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere 2.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 5 °C 2.2: 1.5 h / Reflux View Scheme
Multi-step reaction with 3 steps 1.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere 2.1: sodium nitrite; sulfuric acid; acetic acid / 0.5 h / 5 °C 2.2: 1 h / 50 °C 3.1: hydrogenchloride / water / 1 h / Reflux View Scheme

2,3-difluoroanilline (4519-40-8) + potassium ethyl xanthogenate (140-89-6) → 2-mercapto-7-fluorobenzothiazole (154327-29-4)

Conditions	Yield
In N,N-dimethyl-formamide for 4h; Inert atmosphere; Heating;	100%
In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere;	100%
In N,N-dimethyl-formamide at 160℃; for 4h;	89%

2-(3-((7-(benzyloxy)quinazolin-4-yl)amino)-1H-pyrazol-5-yl)acetic acid (722544-24-3) + 2,3-difluoroanilline (4519-40-8) → 2-(3-{[7-(benzyloxy)quinazolin-4-yl]amino}-1H-pyrazol-5-yl)-N-(2,3-difluorophenyl)acetamide (722544-25-4)

Conditions	Yield
With pyridine; trichlorophosphate at 0 - 20℃; for 2h;	100%

2,3-difluoroanilline (4519-40-8) → 4-bromo-2,3-difluoro-aniline (112279-72-8)

Conditions	Yield
With N-Bromosuccinimide In N,N-dimethyl-formamide for 1h; Cooling with ice;	100%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 0℃; for 1h;	97%
With N-Bromosuccinimide In acetonitrile at 35℃; for 2h;	68%

2,3-difluoroanilline (4519-40-8) → 2,3-difluorobenzenesulphonyl chloride (210532-24-4)

Conditions	Yield
Stage #1: 2,3-difluoroanilline With hydrogenchloride; sodium nitrite In water at -5 - 0℃; for 0.166667h; Ice/NaCl; Stage #2: With thionyl chloride; copper(l) chloride In water at -5℃; for 0.5h;	98%
With hydrogenchloride; acetic acid; mercury; sodium nitrite; copper(I) chloride In water
Stage #1: 2,3-difluoroanilline With hydrogenchloride; sodium nitrite In water at -10℃; for 0.666667h; Stage #2: With hydrogenchloride; sulfur dioxide; copper(l) chloride In water; acetic acid at 0℃;
Stage #1: 2,3-difluoroanilline With hydrogenchloride; acetic acid; sodium nitrite In water at -5℃; Stage #2: With sulfur dioxide; copper(l) chloride In water for 0.25h; Cooling with ice;
Stage #1: 2,3-difluoroanilline With hydrogenchloride; sodium nitrite In water at -10℃; for 0.666667h; Stage #2: With sulfur dioxide; copper(l) chloride In water; acetic acid at 0℃;

1-methanesulfonyl-1H-pyrrole-2,4-dicarboxylic acid 2-methyl ester (845868-07-7) + 2,3-difluoroanilline (4519-40-8) → 4-(2,3-difluoro-phenylcarbamoyl)-1-methanesulfonyl-1H-pyrrole-2-carboxylic acid methyl ester (845868-08-8)

Conditions	Yield
Stage #1: 1-methanesulfonyl-1H-pyrrole-2,4-dicarboxylic acid 2-methyl ester With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1h; Stage #2: 2,3-difluoroanilline With triethylamine In dichloromethane for 1h;	98%

4-chloro-3-formylcoumarin (50329-91-4) + 2,3-difluoroanilline (4519-40-8) → 7,8-difluoro-4-(2-hydroxyphenyl)quinoline-3-carboxylic acid (1394232-19-9)

Conditions	Yield
With sulfuric acid In methanol at 20℃; for 0.0833333h;	98%

2,3-difluoroanilline (4519-40-8) + bis-(2-chloroethyl)amine hydrochloride (821-48-7) → 1-(2,3-difluorophenyl)piperazine hydrochloride

Conditions	Yield
In diethylene glycol dimethyl ether at 130℃; for 15h;	97.9%

2,3-difluoroanilline (4519-40-8) + 2-(4-nitro-1H-pyrazol-1-yl)acetic acid (6645-69-8) → N-(2,3-difluorophenyl)-2-(4-nitro-1H-pyrazol-1-yl)acetamide (786681-72-9)

Conditions	Yield
With pyridine; trichlorophosphate In dichloromethane for 2h;	97%

2,3-difluoroanilline (4519-40-8) + potassium ethyl xanthogenate (140-89-6) → 7-fluoro-1,3-benzothiazole-2(3H)-thione

Conditions	Yield
In N,N-dimethyl-formamide for 2h; Heating;	96%
In 1-methyl-pyrrolidin-2-one at 120℃;

ethylxanthogenate (28563-38-4) + 2,3-difluoroanilline (4519-40-8) → 2-mercapto-7-fluorobenzothiazole (154327-29-4)

Conditions	Yield
In N,N-dimethyl-formamide at 120℃; for 2h;	96%

2,3-difluoroanilline (4519-40-8) + aminosulfonic acid (5329-14-6) + acrylic acid (79-10-7) → 2,4-Difluorocinnamic acid (94977-52-3)

Conditions	Yield
With sulfuric acid; sodium nitrite; palladium diacetate In water	95%

4-chloro-3-formylcoumarin (50329-91-4) + 2,3-difluoroanilline (4519-40-8) → 10,11-difluoro-6H-chromeno[4,3-b]quinolin-6-one (1357063-68-3)

Conditions	Yield
In ethanol at 20℃; for 0.25h; ultrasound irradiation;	94%
In methanol at 20℃; for 0.15h; ultrasound irradiation;	92%
With Amberlyst-15 In ethanol for 2h; Reflux; Inert atmosphere;	78%

2,3-difluoroanilline (4519-40-8) + (3RS,4SR)-1-allyloxy-4-(4-methylphenyl)-2-oxo-pyrrolidine-3-carboxylic acid → (3RS,4RS)-1-allyloxy-N-(2,3-difluorophenyl)-4-(4-methylphenyl)-2-oxopyrrolidine-3-carboxamide

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃; for 17h;	92%

2,3-difluoroanilline (4519-40-8) + 2-bromobenzo[2,3][1,4]oxazepino[7,6-b]quinoline → N-(2,3-difluorophenyl)benzo[2,3][1,4]oxazepino[7,6-b]quinolin-2-amine

Conditions	Yield
With chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); sodium t-butanolate In 1,4-dioxane at 90℃; for 0.75h; Buchwald-Hartwig Coupling; Microwave irradiation;	92%

2,3-difluoroanilline (4519-40-8) + glycerol (56-81-5) → 7,8-Difluoroquinoline

Conditions	Yield
Stage #1: 2,3-difluoroanilline; glycerol With sulfuric acid; sodium iodide at 150 - 180℃; for 4h; Stage #2: With sodium hydroxide In water at 60 - 70℃;	91%
Stage #1: 2,3-difluoroanilline With sulfuric acid at 0 - 20℃; for 1h; Stage #2: glycerol With sodium iodide at 150 - 180℃; for 3h;	91%
With sulfuric acid; sodium 3-nitrobenzenesulfonate at 140℃; for 4h; Condensation; cyclization;	86%
With sulfuric acid; sodium 3-nitrobenzenesulfonate In water at 135℃;
Stage #1: 2,3-difluoroanilline; glycerol With sulfuric acid; sodium 3-nitrobenzenesulfonate In water at 135℃; for 3.5h; Stage #2: With sodium hydroxide In water at 0 - 20℃;

2,3-difluoroanilline (4519-40-8) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-N-(2,3-difluorophenyl)acetamide (804550-60-5)

Conditions	Yield
With sodium hydroxide In diethyl ether at 5 - 20℃; for 1h;	91%
With sodium hydroxide In diethyl ether; water at 5 - 20℃; for 1.33333h;	91%
With potassium carbonate In dichloromethane for 5h;
With potassium carbonate In dichloromethane for 5h;

2,3-difluoroanilline (4519-40-8) + 2-bromo-9-methylbenzo[2,3][1,4]oxazepino[7,6-b]quinoline → N-(2,3-difluorophenyl)-9-methylbenzo[2,3][1,4]oxazepino[7,6-b]quinolin-2-amine

Conditions	Yield
With chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); sodium t-butanolate In 1,4-dioxane at 90℃; for 0.75h; Buchwald-Hartwig Coupling; Inert atmosphere; Microwave irradiation; Sealed tube;	91%

2,3-difluoroanilline (4519-40-8) + 1,2,3-thiadiazole-5-carbonyl azide (58756-32-4) → 1-(2,3-difluorophenyl)-3-(1',2',3'-thiadiazol-5'-yl)urea

Conditions	Yield
In toluene Heating;	90%

2,3-difluoroanilline (4519-40-8) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(2,3-difluorophenyl)acetamide (916483-51-7)

Conditions	Yield
With sodium hydroxide In diethyl ether; water at 5 - 20℃; for 1.33333h;	90%
With sodium hydroxide In diethyl ether; water at 5 - 20℃; for 1.33333h;	90%
Stage #1: 2,3-difluoroanilline With sodium hydrogencarbonate In chloroform at 20℃; for 0.25h; Stage #2: chloroacetyl chloride In chloroform at 20℃; for 2h;

2,3-difluoroanilline (4519-40-8) + 3-methyl-4-nitro-benzoyl chloride (35675-46-8) → N-(2,3-difluoro-phenyl)-3-methyl-4-nitro-benzamide (343975-33-7)

Conditions	Yield
With pyridine for 1h; Heating;	89%

2-(3-((7-(3-chloropropoxy)quinazolin-4-yl)amino)-1H-pyrazol-5-yl)acetic acid (557770-91-9) + 2,3-difluoroanilline (4519-40-8) → 2-(5-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(2,3-difluorophenyl)acetamide (557770-88-4)

Conditions	Yield
With pyridine; trichlorophosphate at 0 - 20℃;	89%
With pyridine; trichlorophosphate In diethyl ether; ethyl acetate at 0 - 20℃; for 23.5h;	89%

4-(piperidin-1-yl)benzaldehyde (10338-57-5) + 2,3-difluoroanilline (4519-40-8) → N-(4-(piperidin-1-yl)benzylidene)-2,3-difluorobenzenamine (1268812-37-8)

Conditions	Yield
With acetic acid In ethanol at 20℃; for 0.5h;	88%

2,3-difluoroanilline (4519-40-8) + acetone (67-64-1) → 2,3-difluoro-N-isopropylaniline

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 12h;	88%

2,3-difluoroanilline (4519-40-8) + 2-chloro-2-(diethoxymethyl)-3-methyloxirane (175983-09-2) → 2-chloro-1,1-diethoxy-3-(2,3-difluorophenylamino)butan-2-ol

Conditions	Yield
With sodium hydrogencarbonate In water; toluene at 40℃; for 36h; Temperature;	88%

bis(benzonitrile)palladium(II) chloride (14220-64-5, 39958-10-6, 15617-18-2) + 2,3-difluoroanilline (4519-40-8) → trans-[PdCl2(2,3-difluoroaniline)2] (919990-57-1)

Conditions	Yield
In ethanol under N2; soln. of PdCl2(C6H5CN)2 (0.26 mmol) added to soln. of 2,3-difluoroaniline (0.52 mmol); refluxed (8 h); hot soln. filtered; solvent removed (vac.); elem. anal.;	87%

2,3-difluoroanilline (4519-40-8) + acryloyl chloride (814-68-6) → N-(2,3-difluorophenyl)prop-2-enamide

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 16h; Inert atmosphere;	87%

[2-(tritylamino)-1,3-thiazol-5-yl]acetic acid (385785-18-2) + 2,3-difluoroanilline (4519-40-8) → N-(2,3-difluorophenyl)-2-[2-(tritylamino)-1,3-thiazol-5-yl]acetamide (723281-43-4)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 50℃; for 18h;	85%

Upstream product

• 87-61-6 1,2,3-trichlorobenzene 
• 67-63-0 isopropyl alcohol 
• 36556-39-5 difluorodichlorobenzene 
• 1435-43-4 1-chloro-3,5-difluorobenzene 
• 136272-32-7 3,4,5-trichloro-2,6-difluoronitrobenzene 
• 136272-33-8 1,2,4-trichloro-3,5-difluoronitrobenzene 
• 367-11-3 ortho-difluorobenzene 
• 1481-57-8 1,2-dibromo-4,5-difluoro-3-nitrobenzene 
• 64695-78-9 1,2-difluoro-4,5-dibromobenzene 
• 771-69-7 2,3,4-trifluoronitrobenzene 
• 211693-73-1 2-amino-3,4-difluoronitro-benzene 

Downstream Products

• 106976-06-1 N-(2,3-difluorophenyl)-3-nitroanthranilic acid 
• 123330-49-4 2,3-difluorophenylazide 
• 123330-58-5 2,2',3,3'-tetrafluorobenzene 
• 123330-54-1 N-benzyl-2,3-difluoroaniline 
• 129589-65-7 1-(tert-butoxycarbonylamino)-2,3-difluorobenzene 
• 195711-22-9 1-(2,3-difluorophenyl)-1H-pyrrole 
• 185010-80-4 2-[(2,3-Difluoro-phenylamino)-methylene]-malonic acid diethyl ester 
• 145241-76-5 7,8-Difluoroquinoline 
• 343975-33-7 N-(2,3-difluoro-phenyl)-3-methyl-4-nitro-benzamide 
• 154327-29-4 2-mercapto-7-fluorobenzothiazole 
• 18355-79-8 N-(2,3-difluoro-phenyl)-acetamide 
• 723281-43-4 N-(2,3-difluorophenyl)-2-[2-(tritylamino)-1,3-thiazol-5-yl]acetamide 
• 557769-44-5 2-(5-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(2,3-difluorophenyl)acetamide 
• 557770-88-4 2-(5-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(2,3-difluorophenyl)acetamide 

Relevant articles and documents

PRODUCTION METHOD OF 2,3-DIHALOGENOANILINE

PROBLEM TO BE SOLVED: To provide a production method of 2,3-dihalogenoaniline in a high yield without high-temperature, high-pressure reaction conditions. SOLUTION: A production method of 2,3-dihalogenoaniline includes a step of substituting the 3-halogeno group of a 1,2,3-trihalogeno-4-nitrobenzene with an amino group to obtain 2,3-dihalogeno-6-nitroaniline, making succinic acid to act on the amino group so as to obtain 1-(2,3-dihalogeno-6-nitrophenyl)pyrrolidin-2,5-dione, reducing the 6-nitro group of the obtained 1-(2,3-dihalogeno-6-nitrophenyl)pyrrolidin-2,5-dione to convert into 6-amino group so as to obtain 1-(2,3-dihalogeno-6-aminophenyl)pyrrolidin-2,5-dione (formula (IV)) and reducing the 6-amino group to cleave 2,5-dioxo-1-pyrrolidinyl group so as to induce to an amino group. COPYRIGHT: (C)2016,JPOandINPIT

HALOGENATED ANILINE AND METHOD FOR PRODUCING SAME

The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed

Process and intermediates for the preparation of 2,6-difluoroaniline

1-Chloro-3,5-difluorobenzene is chlorinated to give 4,6-difluoro-1,2,3-trichlorobenzene which in turn is nitrated and reduced to the corresponding novel aniline, 2,6-difluoro-3,4,5-trichloroaniline. Further reduction of this aniline provides 2,6-difluoroaniline with high selectivity.

AROMATIC FLUORINE CHEMISTRY. PART 5. PREPARATION OF 2,6-DIFLUOROANILINE AND 1,2-DIFLUOROBENZENE

The preparation of 2,6-difluoroaniline and 1,2-difluorobenzene from 1,2,3-trichlorobenzene is described.An isomeric mixture of 1-chloro-2,3-difluorobenzene and 2-chloro-1,3-difluorobenzene is obtained from KF exchange on 1,2,3-trichlorobenzene.Selective dechlorination of 1-chloro-2,3-difluorobenzene with H2 and Pd/C catalyst gives 1,2-difluorobenzene. 2,6-difluoroaniline is obtained via ammonolysis of 2-chloro-1,3-difluorobenzene.

4 AND 5-Halo substituted 2-indanamine compounds

2-Indanamine compounds having 4 and 5-halo substituents are inhibitors of phenylethanolamine N-methyltransferase.