- Synthesis of pyrazine alcaloids from Botryllus leachi. diazines 43
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(Chemical Equation Presented) Regioselective metalation of pyrazines and cross-coupling reactions provides an easy access to botryllazines A and B and to an isomer of botryllazine A with good yields from chloropyrazine.
- Buron, Frederic,Ple, Nelly,Turck, Alain,Queguiner, Guy
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p. 2616 - 2621
(2007/10/03)
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- BENZO ‘ D!AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
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The present invention relates to benzazepine derivatives of formula ( I ) wherein: R1 represents -C3-7 cycloalkyl optionally substituted by C1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
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Page/Page column 23
(2010/02/07)
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- Heterocyclic-ring condensed benzothiazine compound
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The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate. The heterocyclic ring condensed benzothiazine compound of the present invention or a pharmacologically acceptable salt thereof is effective for prevention or remedy of disease, in which a chemical mediator, such as histamine, leukotriene and the like, participate, for example, asthma, allergic coryza, atopic dermatitis, hives, hay fever, gastrointestinal allergy, food allergy and the like. Further, the heterocyclic ring condensed benzothiazine compound of the present invention, its pharmacologically acceptable salt or hydrates thereof is represented by the following formula: In the formula, the ring Het represents an unsaturated heterocyclic ring; R1and R2are the same as or different from each other, and each represents halogen atom, a lower alkyl group that may be substituted with a halogen atom, a lower alkoxy group that may be substituted with a halogen atom, a lower alkyl lower alkoxy group, cyano group; D represents a lower alkylene group and the like that may have a substituent; Q represents, for example, the formula —NR20R2(in the formula, R20and R21are the same as or different from each other, and each represents hydrogen atom, a lower alkyl group that may be substituted with a halogen atom, an aryl group that may have a substituent, an arylalkyl group that may have a substituent, a heteroaryl group that may have a substituent or a heteroarylalkyl group that may have a substituent, or R20and R21may form a 3- to 8-membered ring along with the nitrogen atom to which they are bound); and x represents an integer of from 1 to 2.
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- Studies on Pyrazines. 29. High Regioselective Synthesis of Chloropyrazines from 3-Substituted Pyrazine 1-Oxides
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Reaction of 3-methoxy- or 3-chloropyrazine 1-oxides with refluxing phosphoryl chloride in the presence of amine led to a high regioselective formation of 3-substituted 2-chloropyrazines.In contrast, the use of chloroacetyl chloride instead of phosphoryl chloride enabled different regioselectivity to yield 6-substituted 2-chloropyrazines, particularly 3-methoxycarbonylpyrazine 1-oxide was almost exclusively converted into methyl 6-chloropyrazinecarboxylate under conditions without the amine.
- Sato, Nobuhiro,Fujii, Megumi
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p. 1177 - 1180
(2007/10/02)
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- Synthesis of Derivatives of Pyrazinopyridimidin-4-ones
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3-Alkoxy-2-aminopyrazines have been condensed with ethyl ethoxymethylenemalonate and isopropylidene methoxymethylenemalonate to afford 9-alkoxypyrazinopyrimidin-4-ones substituted in the first case by an ethoxycarbonyl group at 3 position.
- Dennin, F.,Blondeau, D.,Sliwa, H.
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p. 1639 - 1643
(2007/10/02)
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- Studies in the Heterocyclic Series.XIX.Synthesis of 1,4-diazaphenothiazine and its Benzo Derivatives
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1,4-Diazaphenothiazine, the parent compound of this heterocyclic ring has now been prepared from 2,3-dichloropyrazine and 2-aminothiophenol.Replacement of 2,3-dichloropyrazine with 2,3-dichloroquinoxaline and 2,3,6-trichloroquinoxaline led to the corresponding 1,4-diazabenzophenothiazine in good yields.Structural assignments were made by spectroscopic studies and by certain chemical transformations.
- Okafor, Charles O.
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p. 405 - 407
(2007/10/02)
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